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Drug exposure may lead to substance induced psychotic disorder

A recent article published in The American Journal of Psychiatry revealed that people with a heredity of alcohol and drug use and those with a mild risk of psychosis running in the family have a high susceptibility of developing psychotic disorder induced because of substance abuse. Lead author Kenneth S. Kendler, stated that it was therefore imperative to comprehend the causes of substance-induced psychotic disorder as it can help in understanding other psychotic syndromes.

The investigators extracted data of people grappling with substance-induced psychotic disorders from the Swedish national registries. Nearly 7,606 patients were used as study subjects and were investigated between 1997 and 2015. The study participants were followed for a period of 7 years. The investigators analyzed the data to establish a familial risk score of drug abuse, alcohol use, and nonaffective psychosis. The major emphasis of the investigation was to calculate the accumulative hazard pertaining to schizophrenia for psychotic disorders induced by substances.

Researchers used prediction risk model

The authors discovered that a great increase in standardized familial risk scores for drug abuse, alcohol use disorder (AUD), along with minor increase in familial risk scores for nonaffective psychosis were registered. The accumulated risk of the development of schizophrenia was found to be 11.3 percent. People with alcohol-induced psychotic ailments were at a lower risk of schizophrenia, compared to people with cannabis-induced psychotic disorder who were at a greater risk.

Male sex, alcohol use disorder (AUD), further episodes of drug abuse, substance-induced psychotic disorder, and screening of substance-induced psychotic disorder at an early age were employed as the predictors for schizophrenia development. The researchers also identified that 47 percent of the subject population developing schizophrenia belonged to the higher two risk deciles, using a prediction risk model.

Increased susceptibility to psychosis and substantial exposure to drugs increased likelihood of substance-induced psychotic disorder

Between the individuals who developed schizophrenia and those who did not, AUD, and familial risk scores for drug abuse didn’t demarcate significantly, however, this was affected by nonaffective psychosis. Furthermore, familial possibility scores for nonaffective psychosis were vague between people with schizophrenia with and without preceding substance-induced psychosis.

Following the analysis, Kendler and the team concluded that an increased propensity to psychosis and substantial exposure to drugs increased the likelihood of developing substance-induced psychotic disorder. Development of schizophrenia subsequent to the psychotic disorder induced by a substance was clearly explained as a disorder which was triggered by drug usage in individuals highly vulnerable rather than saying that it is a disorder manifested by drug exposure only.

Seeking help for substance addiction

In substance-induced psychosis, it is indispensable to discontinue abusing the substance; though, the reality could be more complex. Overcoming an addiction can get challenging and withdrawal symptoms are virtually inescapable after long-standing substance abuse. Moreover, the mental illness symptoms can become intolerable to the extent that the distressed individuals may resort to self-medicating, or may lose control of impulses which can knock-back any resolve to abstain. When such a thing happens, that is a mental health disorder co-exists with a substance use disorder (SUD), it is referred to as dual diagnosis.

If you or a loved one is struggling with a SUD and a mental illness and is looking for a reliable behavioral health center, get in touch with the 24/7 Recovery Helpline by calling our 24/7 alcohol helpline 855-441-4405. 24/7 Recovery Helpline is linked with multiple behavioral health centers that offer comprehensive evidence-based treatment plans for patients dealing with substance abuse issues, as well as mental health disorders. You can also chat online with our experts available 24/7 at our drug addiction help online to get guidance about dual-diagnosis treatment centers and programs offered.

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